A former slave arrives in Yellowstone City, Montana, a desolate former boomtown now on the decline, looking for a place to call home. On that same day, a local prospector discovers gold - and is murdered.

As the human species adapts to a synthetic environment, the body undergoes new transformations and mutations. Accompanied by his partner Caprice, celebrity performance artist Saul Tenser showcases the metamorphosis of his organs. Meanwhile, a mysterious group tries to use Saul's notoriety to shed light on the next phase of human evolution.