In high school, Schmidt was a dork and Jenko was the popular jock. After graduation, both of them joined the police force and ended up as partners riding bicycles in the city park. Since they are young and look like high school students, they are assigned to an undercover unit to infiltrate a drug ring that is supplying high school students synthetic drugs.

Desperate to be the top cops on the force, two misfit detectives break free from their desk jobs and stumble onto the biggest case of their careers.